開発プローブ

当研究室で開発した pH プローブ AcidiFluor ORANGE^TM が五稜化薬株式会社より販売されております。
詳しくはこちらをご覧ください。

その他：Promega KK
　　　　Merck KGaA

代表的文献

• 2024
  

  Rinako Miyano, Hirokazu Sakamoto, Kenzo Hirose, and Takeshi Sakaba.
  RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter release at hippocampal mossy fiber terminals. eLife (2024) PubMed

• 2023
  

  Tomofumi Yoshida, Koh-Ichiro Takenaka, Hirokazu Sakamoto, Yusuke Kojima, Takumi Sakano, Koyo Shibayama, Koki Nakamura, Kyoko Hanawa-Suetsugu, Yasunori Mori, Yusuke Hirabayashi, Kenzo Hirose, Shigeo Takamori.
  Compartmentalization of soluble endocytic proteins in synaptic vesicle clusters by phase separation. (2023) PubMed
  
  Ryota Fukaya, Himawari Hirai, Hirokazu Sakamoto, Yuki Hashimotodani, Kenzo Hirose, Takeshi Sakaba. Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses. (2023) PubMed

• 2021

  Yoshie Endo, Daisuke Asanuma, Shigeyuki Namiki, Kei Sugihara, Kenzo Hirose, Akiyoshi Uemura, Yoshiaki Kubota & Takashi Miura. Quantitative modeling of regular retinal microglia distribution. Sci. Rep. 11, Article number: 22671 (2021)
  PubMed
  
  TAKAGI Takeru, UENO Tasuku, NOMURA Yusuke, ASANUMA Daisuke, URANO Yasuteru, URANO Yasuteru (AMED). Visualization and manipulation of actin cytoskeleton with small-molecular probes. Sci. Adv. 59 S301 (WEB ONLY) ChemRxiv
  
  Kitajima, N., Takikawa, K., Sekiya, H., Asanuma, D., Sakamoto, H., Namiki, S., lino, M. and Hirose, K. In vivo Fluorescence Imaging of Extracellular ATP in the Mouse Cerebral Cortex with a Hybrid-type Optical Sensor.
  Bio-protocol 11(11): e4046. (2021) PubMed
  
  Toshimitsu Aritake, Hideitsu Hino, Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose, Noboru Murata. Fast and robust multiplane single-molecule localization microscopy using a deep neural network. Elsevier 451, 3 279-289 (2021)Elsevier
  

• 2020

  Aritake, T., Hino, H., Namiki, S., Asanuma, D., Hirose, K., & Murata, N. (2020). Single-molecule localization by voxel-wise regression using convolutional neural network. Elsevier (2020) Elsevier
  
  Kitajima, N., Takikawa,K., Sekiya, H., Satoh, K., Asanuma, D., Sakamoto, H., Takahashi, S., Hanaoka, K., Urano, Y., Namiki, S., Iino,M., Hirose K. Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor. eLife 2020;9:e57544 doi: 10.7554/eLife.57544 (2020) PubMed Free PMC article
  
  Okubo, Y. and Iino, M. Visualization of astrocytic intracellular Ca2+ mobilization. J. Physiol. 589, 1671-1681 (2020) PubMed
  
  Takahashi, S., Hanaoka, K., Okubo, Y., Echizen, H., Ikeno, T., Komatsu, T., Ueno, T., Hirose, K., Iino, M., Nagano, T. and Urano, Y. Rational design of a near-infrared fluorescence probe for Ca2+ based on phosphorus-substituted rhodamines utilizing photoinduced electron transfer. Chem. Asian J. 15, 524-530 (2020) PubMed
  
  Okubo, Y., Iino, M. and Hirose, K. Store-operated Ca2+ entry-dependent Ca2+ refilling in the endoplasmic reticulum in astrocytes. Biochem. Biophys. Res. Commun. 522, 1003-1008 (2020) PubMed

• 2019

  Okubo, Y., Kanemaru, K., Suzuki, J., Kobayashi, K., Hirose, K. and Iino, M. Inositol 1,4,5-trisphosphate receptor type 2-independent Ca2+ release from the endoplasmic reticulum in astrocytes. Glia 67, 113-124 (2019) PubMed

• 2018

  Taichi Onishi, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose. The Altered Supramolecular Structure of Dopamine D2 Receptors in Disc1-deficient Mice. Affiliations expand Sci Rep. 2018 Jan 26;8(1):1692. PubMed
  
  Sakamoto H, Ariyoshi T, Kimpara N, Sugao K, Taiko I, Takikawa K, Asanuma D, Namiki S and Hirose K. Synaptic weight set by Munc13-1 supramolecular assemblies. Nature Neuroscience 21:41-49 (2018) PubMed

• 2015
  

  Masayuki Isa, Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose. Spatiotemporal Control of Receptor Tyrosine Kinase Activity by Caged Ligands. Chemistry Letters, Volume 44, Issue 2, February 2015, Pages 150?151 (2015) Chemistry Letters

• 2014

  Takikawa K, Asanuma D, Namiki S, Sakamoto H, Ariyoshi T, Kimpara N, Hirose K. High-Throughput Development of a Hybrid-Type Fluorescent Glutamate Sensor for Analysis of Synaptic Transmission. Angew Chem Int Ed Engl (2014) PubMed
  
  Isa M, Asanuma D, Namiki S, Kumagai K, Kojima H, Okabe T, Nagano T, Hirose K. High-Throughput Screening System To Identify Small Molecules That Induce Internalization and Degradation of HER2. ACS Chem Biol. 9:2237-41 (2014) PubMed
  
  Asanuma D, Takaoka Y, Namiki S, Takikawa K, Kamiya M, Nagano T, Urano Y, Hirose K. Acidic-pH-Activatable Fluorescence Probes for Visualizing Exocytosis Dynamics. Angew Chem Int Ed Engl. 53:6085-9 (2014) PubMed

  Ishino Y, Hayashi Y, Naruse M, Tomita K, Sanbo M, Fuchigami T, Fujiki R, Hirose K, Toyooka Y, Fujimori T, Ikenaka K, Hitoshi S.　Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells.　The Journal of Neuroscience 34(8) 3067-78 (2014) PubMed
  

• 2013

  Kanemaru K, Kubota J, Sekiya H, Hirose K, Okubo Y, Iino M. Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury. ProcNatlAcadSci USA.110:11612-7 (2013) PubMed

• 2012

  Tokunaga T, Namiki S, Yamada K, Imaishi T, Nonaka H, Hirose K, Sando S. Cell surface-anchored fluorescent aptamer sensor enables imaging of chemical transmitter dynamics. Am Chem Soc. 134:9561-4 (2012) PubMed

• 2011
  

  Sugao K, Hirose K. Enzymatic production of RNAi libraries from cDNAs and high-throughput selection of effective shRNA expression constructs. Methods Mol Biol. 729 123-39 2011:729:123-39. doi: 10.1007/978-1-61779-065-2_8.  PubMed

• 2010
  

  Takuji Tsuji, Yusaku Ohta, Yuya Kanno, Kenzo Hirose, Kazumasa Ohashi, Kensaku Mizuno. Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Mol Biol Cell (2010) PubMed
  
  Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature.464:1313-9 (2010) PubMed
  
  Okubo Y, Sekiya H, Namiki S, Sakamoto H, Iinuma S, Yamasaki M, Watanabe M, Hirose K , Iino M. Imaging extrasynaptic glutamate dynamics in the brain. ProcNatlAcadSci USA. 107:6526-31 (2010) PubMed

• 2008

  Yogo T, Urano Y, Mizushima A, Sunahara H, Inoue T, Hirose K, Iino M, Kikuchi K, Nagano T. Selective photo-inactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer. ProcNatlAcadSci USA. 105:28-32 (2008) PubMed

• 2007

  Kanemaru K, Okubo Y, Hirose K , Iino M. Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes. Eur J Neurosci. 27:8957-66. (2007) PubMed
  
  Namiki S, Sakamoto H, Iinuma S, Iino M & Hirose K. Optical glutamate sensor for spatiotemporal analysis of synaptic transmission. Eur J Neurosci. 25:2249-2259 (2007) PubMed
  
  Hashido M, Hayashi K, Hirose K, Iino M. Ca2+ lightning conveys cell-cell contact information inside the cells. EMBO Rep. 7:1117-23 (2007) PubMed

• 2006

  Ishii K, Hirose K, Iino M. Ca2+ shuttling between endoplasmic reticulum and mitochondria underlying Ca2+ oscillations. EMBO Rep. 7:390-6 (2006) PubMed

• 2005

  Namiki S, Kakizawa S, Hirose K , Iino M. NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum. J Physiol. 566:849-63 (2005)PubMed
  
  Hashimoto A, Hirose K , Iino M. BAD detects coincidence of G2/M phase and growth factor deprivation to regulsis. Biol Chem. 280:26225-32 (2005) PubMed
  
  Urano Y, Kamiya M, Kanda K, Ueno T, Hirose K, Nagano T. Evolution of fluorescein as a platform for finely tunable fluorescence probes. Am Chem Soc. 127:4888-94 (2005) PubMed

• 2003

  Tomida T, Hirose K, Takizawa A, Shibasaki F, Iino M. NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J. 22:3825-3832 (2003) PubMed

• 2001

  Okubo Y, Kakizawa S, Hirose K, Iino M. Visualization of IP3 dynamics reveals a novel AMPA receptor-triggered IP3 production pathway mediated by voltage-dependent Ca2+ influx in Purkinje cells. Neuron 32:113-122 (2001) PubMed

• 1999

  Hirose K, Kadowaki S, Tanabe M, Takeshima H, Iino M. Spatio-temporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns. Science 284:1527-1530 (1999) PubMed

• 1994

  Hirose K, Iino M. Heterogeneity of channel density in inositol- 1,4,5-trisphosphate-sensitive Ca2+ stores. Nature 372:791-794 (1994) PubMed

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